Why DHT Causes Hair Loss - MyHairSmart. ANDROGENIC ALOPECIA, hair growth solution

DHT and Hair Loss: Understanding Androgenic Alopecia and Natural Blockers

Written by: prerna khemka


Millions suffer from hair loss, but did you know a hormone called DHT is often the culprit?

Hair loss is a common problem that affects both men and women. It can be caused by a variety of factors, including genetics, hormones, and medical conditions. One of the most common causes of hair loss is dihydrotestosterone (DHT).

What is DHT?

DHT stands for Dihydrotestosterone, a hormone derived from testosterone, a primary male sex hormone. DHT is created through the conversion of testosterone by the enzyme 5-alpha-reductase, primarily in the prostate, skin, follicles, and liver.

DHT plays a significant role in the development of male characteristics such as body hair growth and prostate growth. It's more potent than testosterone and is crucial for male sexual development during the fetal and puberty stages.

However, high levels of DHT are associated with certain health issues. For men, these include conditions like male pattern baldness and benign prostatic hyperplasia (BPH). The role of DHT in hair loss is particularly well-known; it tends to shrink hair follicles, leading to the thinning and eventual loss of hair.

DHT and Hair Loss: The Connection

The connection between Dihydrotestosterone (DHT) and hair loss, particularly male pattern baldness, is a complex interplay of hormonal activity and genetic predisposition. Here's an explanation of how this connection works:

How DHT Affects Hair Follicles

  1. Binding to Androgen Receptors: DHT exerts its effects on hair follicles by binding to androgen receptors located on the follicles. This binding is crucial in determining how the hair follicle will respond to DHT.
  2. Miniaturization of Hair Follicles: Once DHT binds to these receptors, it triggers a process called miniaturization in susceptible hair follicles. Miniaturization refers to the progressive shrinking of the hair follicle. This shrinkage affects the hair growth cycle.
  3. Disruption of Hair Growth Cycle: DHT shortens the Anagen phase (growth phase) of the hair growth cycle and extends the Telogen phase (resting phase). This results in shorter, thinner hair strands over time. Eventually, the follicles shrink to a point where they can no longer produce visible hair, leading to hair thinning and balding areas.
  4. Regional Sensitivity: The effects of DHT are not uniform across the scalp. Hair follicles in certain areas, like the temples and crown, are typically more sensitive to DHT. This leads to the characteristic pattern of hair loss seen in male pattern baldness.

Genetic Predisposition to DHT Sensitivity in Hair Follicles

  1. Genetic Factors: The sensitivity of hair follicles to DHT is largely determined by genetic factors. This explains why male pattern baldness often runs in families.
  2. Variation in Androgen Receptor Genes: Variations or mutations in the genes responsible for androgen receptors can influence how strongly DHT affects the hair follicles. Some individuals may have genetic variations that make their hair follicles more susceptible to DHT.
  3. Inherited Sensitivity: The pattern and progression of hair loss are also inherited. If close family members have experienced male pattern baldness, there's a higher likelihood of similar patterns of hair loss in offspring.
  4. Ethnic Variations: Research has shown that there are ethnic variations in DHT sensitivity and the prevalence of male pattern baldness, further indicating the role of genetic factors.

The connection between DHT and hair loss is rooted in the biological interaction of DHT with hair follicles and the underlying genetic predisposition that dictates the sensitivity of these follicles to DHT.

Main Causes Of Hair Loss

Hair loss can occur due to a variety of reasons, and it's often a result of multiple factors. Here are the main causes of hair loss:

DHT (Dihydrotestosterone): Hormone linked to hair loss. Hair Loss: Genetic, lifestyle, and environmental factors. Treatment Options: Addressing hair loss. Scalp Massage Benefits: Stimulating hair growth. Hair Growth Solutions: Natural methods to promote growth. Alopecia: Various forms of hair loss. Androgenic Alopecia: Genetic pattern baldness. Natural DHT Blockers: Substances inhibiting DHT production.
  1. Genetic Factors (Hereditary Hair Loss): The most common cause of hair loss is a hereditary condition called male-pattern baldness or female-pattern baldness. It usually occurs gradually and in predictable patterns — a receding hairline and bald spots in men and thinning hair along the crown of the scalp in women.
  2. Hormonal Changes: A variety of conditions can cause permanent or temporary hair loss, including hormonal changes due to pregnancy, childbirth, menopause, and thyroid problems.
  3. Medications and Supplements: Hair loss can be a side effect of certain drugs, such as those used for cancer, arthritis, depression, heart problems, gout, and high blood pressure.
  4. Poor Nutrition: Lack of certain nutrients in the diet, such as iron, protein, and certain vitamins, can contribute to hair loss.
  5. Ageing: As people age, hair tends to gradually thin. Other factors, such as lifestyle choices, can cause additional hair loss.
  6. Psychological Factors: Conditions like stress or anxiety can lead to hair shedding.

It's important to note that hair loss can result from a combination of these factors, and the specific cause or causes can vary from person to person. If someone is concerned about hair loss, it's a good idea to consult a hairsmart or a dermatologist to determine the underlying cause and appropriate treatment options.


There are a number of medications that can be used to block the effects of DHT on hair follicles. These include:

  • Finasteride (Propecia): Finasteride is a medication that is taken orally. It works by blocking the conversion of testosterone to DHT. Finasteride is approved by the FDA for the treatment of male pattern hair loss.
  • Minoxidil (Rogaine): Minoxidil is a medication that is applied to the scalp. It works by increasing blood flow to the scalp and stimulating hair growth. Minoxidil is available over-the-counter and by prescription.
  • The HairSmart Program: For those patients that do not wish to take prescription medications with side effects, we have a range of products, repair vitamins and topical solutions combined with Laser Therapy or Laser Cap to reduce hair loss and thicken native hair. Internationally renowned double board certified Plastic Surgeon, Dr. Stanley Okoro said he "Compared to finasteride, I prefer a good natural DHT blocker" and prescribes HairSmart's DHT Blocker to his post-transplant patients as well as to women.


Hair transplantation surgery can be used to transplant hair follicles from one area of the scalp to another. This is a permanent solution for hair loss.

Lifestyle Changes

There are a number of lifestyle changes that can help to reduce your risk of hair loss, including:

  • Maintaining a Healthy Weight: Obesity can increase your risk of hair loss.
  • Reducing Stress: Stress can trigger hair loss in some men.
  • Avoiding Smoking: Smoking can damage hair follicles and contribute to hair loss.
  • Eating a Healthy Diet: A healthy diet is essential for promoting hair growth. Incorporating various "foods for hair growth" into your daily regimen can provide the necessary nutrients to support healthy hair.

If you are concerned about hair loss, get in contact with a dedicated team of hair loss professionals to see if you are a candidate for treatment. There are a number of treatments available, including our range of solutions for hair retention and hair growth.

Image of Author Prerna Khemka

Prerna Khemka

Our founder, Prerna Khemka, confronted hair loss in her twenties. Fueled by a profound passion for Ayurveda and equipped with insights from Western technology, she embarked on a transformative odyssey. Determined to find a solution that resonated with her cultural roots, Prerna delved into extensive research and innovation. The result? A line of clean, effective products that not only revived her own hair but also empowered countless others facing similar challenges.